Monodisperse and Uniform Mesoporous Silicate Nanosensitizers Achieve Low‐Dose X‐Ray‐Induced Deep‐Penetrating Photodynamic Therapy. Issue 16 (8th March 2019)

• Record Type: Journal Article
• Authors: Sun, Wenjing; Shi, Tianhang; Luo, Li; Chen, Xiaomei; Lv, Peng; Lv, Ying; Zhuang, Yixi; Zhu, Jinjie; Liu, Gang; Chen, Xiaoyuan; Chen, Hongmin
• Is Part Of: Advanced materials. Volume 31:Issue 16(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-08
• Subjects: deep penetration -- low radiation dosage -- radiotherapy -- silicate nanoscintillators -- X‐PDT; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201808024
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: X‐ray‐induced photodynamic therapy (X‐PDT) combines both the advantages of radiotherapy (RT) and PDT, and has considerable potential applications in clinical deep‐penetrating cancer therapy. However, it is still a major challenge to prepare monodisperse nanoscintillators with uniform size and high light yield. In this study, a general and rapid synthesis method is presented that can achieve large‐scale preparation of monodisperse and uniform silicate nanoscintillators. By simply adjusting the metal dopants, silicate nanoscintillators with controllable size and X‐ray‐excited optical luminescence (450–900 nm) are synthesized by employing a general ion‐incorporated silica‐templating method. To make full use of external radiation, the silicate nanoscintillators are conjugated with photosensitizer rose bengal and arginylglycylaspartic acid (RGD) peptide, making them intrinsically dual‐modal targeted imaging probes. Both in vitro and in vivo experiments demonstrate that the silicate nanosensitizers can accumulate effectively in tumors and achieve significant inhibitory effect on tumor progression under low‐dose X‐ray irradiation, while minimally affecting normal tissues. The insights gained in this study may provide an attractive route to synthesize nanosensitizers to overcome some of the limitations of RT and PDT in cancer treatment. Abstract : A metal‐incorporated mesoporous silica nanosensitizer is synthesized, which achieves low‐dose X‐ray‐induced deep‐penetrating photodynamic therapy. This efficient killing of cancer cells is attributed to the synergy of radiotherapy and photodynamic therapy. The present research is of great value to the development of silicate‐based X‐ray‐induced photodynamic therapy for cancer management.