Biocompatible Non‐Toxic Porous Polymeric Materials Based on Carbonate‐ and Phthalate‐Containing Dimethacrylates. Issue 14 (11th April 2019)

• Record Type: Journal Article
• Authors: Kovylin, Roman S.; Baten'kin, Maxim A.; Kulikova, Tatyana I.; Egorikhina, Marfa N.; Charikova, Irina N.; Gusev, Sergey A.; Rubtsova, Yu. P.; Mlyavykh, Sergey G.; Aleynik, Diana Ya.; Chesnokov, Sergei A.; Fedushkin, Igor L.
• Is Part Of: ChemistrySelect. Volume 4:Issue 14(2019)
• Page Start: 4147
• Page End: 4155
• Publication Date: 2019-04-11
• Subjects: Bone Grafting -- Cytotoxicity -- Mesenchymal Stem Cells -- Photopolymerization -- Porous Polymers; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201803810
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Polymer monolith materials of 2 mm thickness with open interconnected pores were obtained by a visible light induced radical polymerization of carbonate‐ or phthalate containing dimethacrylate in the presence of aliphatic alcohols (60 to 70 wt %) as porogenic additives. Obtained materials absorb water easily and reveal a specific surface area of 3.1 to 21.5 m 2 g −1 and a porosity of 55–72%. According SEM data the porous monoliths consist of polymer particles (size up to 1 μm) that form 3D structures with a pore size up to 5 μm for poly(carbonatedimethacrylate) and tens of microns for phthalate‐containing polydimethacrylates. Mesenchymal stem cells from the bone marrow (MSC‐BM) of the pig were picked out and characterized. The MTT (3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide) tests on polymers obtained have shown their non‐cytotoxicity. MSC‐BMs spread out well on the polymeric samples and retained their viability and typical morphology during 7 days. Adhesion and viability of MSCs on the surface of materials were detected by calcein staining. The data obtained indicate that the porous polymers derived from dimethacrylates might be promising for construction of plastics for bone grafting. Abstract : Biocompatible non‐cytotoxic porous monolith materials were obtained by photopolymerization of dimethacrylates with primary alcohols. Polymers reveal a porosity of 55–72% with a pore size of five to tens of microns. High cell adhesion, preservation of cell viability and maintenance of their morphology were observed when mesenchymal stem cells from the bone marrow (MSC‐BM) were cultivated on the polymes.