Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines. Issue 31 (29th March 2019)

• Record Type: Journal Article
• Authors: Huo, Chang-Xin; Dhara, Debashis; Baliban, Scott M.; Tahmasebi Nick, Setare; Tan, Zibin; Simon, Raphael; Misra, Anup Kumar; Huang, Xuefei
• Is Part Of: Chemical communications. Volume 55:Issue 31(2019)
• Page Start: 4519
• Page End: 4522
• Publication Date: 2019-03-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc08622b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The conjugate of a synthetic Salmonella Enteritidis tetrasaccharide with bacteriophage Qβ induced powerful anti-glycan IgG responses for complete protection from lethal challenges of bacteria. Abstract : The first synthetic carbohydrate based potential anti- Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.