A gadolinium-complex-based theranostic prodrug for in vivo tumour-targeted magnetic resonance imaging and therapy. Issue 31 (29th March 2019)
- Record Type:
- Journal Article
- Title:
- A gadolinium-complex-based theranostic prodrug for in vivo tumour-targeted magnetic resonance imaging and therapy. Issue 31 (29th March 2019)
- Main Title:
- A gadolinium-complex-based theranostic prodrug for in vivo tumour-targeted magnetic resonance imaging and therapy
- Authors:
- Yang, Zhaoxuan
Lin, Hongyu
Huang, Jiaqi
Li, Ao
Sun, Chengjie
Richmond, Jonathan
Gao, Jinhao - Abstract:
- Abstract : A molecular theranostic prodrug for treatment of tumour and real-time monitoring via MRI in vivo was reported. Abstract : Here we report a target-specific theranostic prodrug (1a ) containing Gd–DOTA, biotin, and camptothecin (CPT) along with a disulfide self-immolative linker. This prodrug exhibits selective targeting towards tumour cells and tissues, stimuli-responsive controlled release, enhanced anticancer efficacy, and accurate diagnosis and real-time monitoring via contrast-enhanced magnetic resonance imaging (MRI).
- Is Part Of:
- Chemical communications. Volume 55:Issue 31(2019)
- Journal:
- Chemical communications
- Issue:
- Volume 55:Issue 31(2019)
- Issue Display:
- Volume 55, Issue 31 (2019)
- Year:
- 2019
- Volume:
- 55
- Issue:
- 31
- Issue Sort Value:
- 2019-0055-0031-0000
- Page Start:
- 4546
- Page End:
- 4549
- Publication Date:
- 2019-03-29
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c9cc01816f ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 9845.xml