Additive-free regio- and diastereoselective construction of fully-substituted isoxazolidines employing diazo compounds. Issue 8 (26th February 2019)

• Record Type: Journal Article
• Authors: Gupta, Ekta; Zaheer, Mohd Khalid; Kant, Ruchir; Mohanan, Kishor
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 8(2019)
• Page Start: 1109
• Page End: 1113
• Publication Date: 2019-02-26
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo01421c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient additive-free three-component access to densely functionalized isoxazolidines using diazo compounds, nitrosoarene, and allenic esters has been uncovered. Abstract : An efficient additive-free three-component reaction of trifluorodiazoethane, nitrosobenzene, and allenic esters has been uncovered. This protocol provides easy access to a variety of trifluoromethylated isoxazolidines with good functional group tolerance. Moreover, this methodology was found to be extendable to α-diazomethylphosphonate providing phosphonylated isoxazolidines. The utility of these products has been demonstrated by the expedient synthesis of trifluoromethylated lactam.