DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Issue 31 (11th March 2019)

• Record Type: Journal Article
• Authors: Gao, Jun; Byrd, Alicia K.; Zybailov, Boris L.; Marecki, John C.; Guderyon, Michael J.; Edwards, Andrea D.; Chib, Shubeena; West, Kirk L.; Waldrip, Zachary J.; Mackintosh, Samuel G.; Gao, Zhaofeng; Putnam, Andrea A.; Jankowsky, Eckhard; Raney, Kevin D.
• Is Part Of: Chemical communications. Volume 55:Issue 31(2019)
• Page Start: 4467
• Page End: 4470
• Publication Date: 2019-03-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc10091h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Abstract : We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes, suggesting new potential roles for these helicases in disruption of quadruplex structures in RNA.