A highly selective H/D exchange reaction of 1, 4-dihydropyridines. Issue 15 (2nd April 2019)

• Record Type: Journal Article
• Authors: Wang, Kaiqian; Chen, Xiaoping; Peng, Xiao; Wang, Ping; Liang, Feng
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 15(2019)
• Page Start: 3845
• Page End: 3852
• Publication Date: 2019-04-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob00575g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A highly selective H/D exchange protocol of Hantzsch ester derivatives as well as related drugs was developed. Abstract : Herein, we report a simple, economical, and effective acid-mediated method for the in situ deuteration of Hantzsch esters and their 4-substituted derivatives, including some drugs that constitute important calcium channel blockers which are effective for hypertension treatment. Hydrogen isotope exchange occurred selectively at α-alkyl C–H bonds in the 2, 6-substituents.