Novel heparin-loaded mesoporous tubular micromotors formed via template-assisted electrochemical deposition. Issue 16 (25th March 2019)

• Record Type: Journal Article
• Authors: Wang, Qi; Wang, Yan; Guo, Baoyan; Shao, Shuibin; Yu, Yueqi; Zhu, Xiaotan; Wan, Mimi; Zhao, Bo; Bo, Chi; Mao, Chun
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 16(2019)
• Page Start: 2688
• Page End: 2695
• Publication Date: 2019-03-25
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00131j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A novel kind of mesoporous tubular micromotor used to load heparin (Hep) and formed via template-assisted electrochemical deposition is presented. Abstract : Based on the concept of the active drug delivery of micro- and nanomotors and the longer cycle time in the blood for drug-loaded tubular particles, it is important to develop novel tubular micromotors that could increase drug loading and achieve more effective treatments in the biomedical field. Here, a novel kind of mesoporous tubular micromotor used to load heparin (Hep) and formed via template-assisted electrochemical deposition is presented. Firstly, the mesoporous tubular micromotors were composed of poly(3, 4-ethylenedioxythiophene) (PEDOT), mesoporous silica (MS) and manganese dioxide (MnO2 ), and were simply fabricated via template-assisted electrochemical growth. Then, the drug Hep was loaded into PEDOT/MS/MnO2 via a simple soaking process. Finally, the release process, cytotoxicity, and blood compatibility tests and motion study for these mesoporous tubular micromotors of PEDOT/MS/MnO2 -Hep were performed. Results indicated that the micromotors we prepared showed good controlled release of Hep, anticoagulant effects, non-cytotoxicity and autonomous motion ability. The new drug carrier and motion mode will give rise to more potential applications of Hep in the biomedical field.