Controllable assembly of a novel cationic gemini surfactant containing a naphthalene and amide spacer with β-cyclodextrin. Issue 15 (21st March 2019)

• Record Type: Journal Article
• Authors: Zhu, Bo; Jia, Lihua; Guo, Xiangfeng; Yin, Jianxin; Zhao, Zhenlong; Chen, Nannan; Chen, Shuxuan; Jia, Yue
• Is Part Of: Soft matter. Volume 15:Issue 15(2019)
• Page Start: 3198
• Page End: 3207
• Publication Date: 2019-03-21
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/c9sm00172g
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : A novel cationic gemini surfactant (C12 NDDA) with a spacer containing naphthalene and amides was successfully synthesized. Abstract : A novel cationic gemini surfactant (C12 NDDA) with a spacer containing naphthalene and amides was successfully synthesized. The assembly of C12 NDDA with β-cyclodextrin (β-CD) was investigated using various techniques including transmission electron microscopy, proton nuclear magnetic resonance ( 1 H NMR), and scanning electron microscopy. Tuning the C12 NDDA concentration and the C12 NDDA/β-CD molar ratio allowed the production of different assembled aggregate morphologies such as micelles, vesicles, nanowires, nanorods, and hydrogels. Investigation of the inclusion mechanisms of C12 NDDA and β-CD by 1 H NMR revealed that hydrophobic interactions, hydrogen bonding, π–π stacking, and electrostatic forces play key roles in the assembly process. The antimicrobial activities of the C12 NDDA/ x β-CD ( x = 0–4) inclusion complexes were tested against Gram-negative bacteria ( Escherichia coli and Salmonella ) and Gram-positive bacteria ( Staphylococcus aureus and Streptococcus ), and very low minimum inhibitory concentrations of 0.078–0.31 μg mL −1 were observed. Thus, this newly synthesized gemini surfactant and its inclusion complexes exhibit potential as superior broad-spectrum disinfectants for various biomedical and biotechnological applications.