Asymmetric cyclizations via a sequential Michael addition/Conia-ene reaction by combining multifunctional quaternary phosphonium salt and silver catalysis. Issue 18 (3rd May 2019)

• Record Type: Journal Article
• Authors: Fang, Guosheng; Zheng, Changwu; Cao, Dongdong; Pan, Lu; Hong, Haoran; Wang, Hongyu; Zhao, Gang
• Is Part Of: Tetrahedron. Volume 75:Issue 18(2019)
• Page Start: 2706
• Page End: 2716
• Publication Date: 2019-05-03
• Subjects: Asymmetric cyclization -- Sequential catalysis -- Multifunctional quaternary phosphonium salt -- Silver catalysis -- Chiral ion pair; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2019.03.045
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A one-pot asymmetric Michael addition/Conia-ene reaction sequence, catalyzed by combination of a dipeptide-derived multifunctional quaternary phosphonium salt and Ag2 CO3 has been developed, which provides a series of synthetically important chiral methylenecyclopentane derivatives in moderate to excellent yields (up to 97%) and enantioselectivities (up to 93%). Graphical abstract: Image 1