Fabrication and characterization of chitosan film impregnated ciprofloxacin drug: A comparative study. (March 2019)

• Record Type: Journal Article
• Authors: Rathore, Hanumant Singh; Senthilvelan, T.; Vasantharaja, Raguraman; Abraham, L. Stanley; Prakash, Dhanasekaran; Sivagnanam, Uma Tirichurapalli; Gupta, Sanjeev
• Is Part Of: Biocatalysis and agricultural biotechnology. Number 18(2019)
• Publication Date: 2019-03
• Subjects: Chitosan film -- Wound healing -- FTIR -- SEM -- in-vitro biocompatibility study; Agricultural biotechnology -- Periodicals; Enzymes -- Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.bcab.2019.101078
• Languages: English
• ISSNs: 1878-8181

Abstract

Abstract: Present study focuses on fabrication of biofilm from chitosan (natural polymer) for loading of the drug to heal the wound. The chitosan based film serves various advantages like biocompatibility, cost effective, easy formulation and sustained drug delivery for wound healing. Three different concentrations of chitosan (Ch) films were prepared like 1% (Ch1), 1.5% (Ch1.5) and 2% (Ch2). These films were impregnated with ciprofloxacin drug and they were characterized by various parameters like thickness, tensile strength, in-vitro drug release and swelling properties. The chemical structure and morphology of drug loaded biofilms were analyzed by fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analysis and their antibacterial efficacy was also evaluated against bacteria such as Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa . The in-vitro biocompatibility was evaluated using NIH 3T3 fibroblast cell lines. The results revels that the ciprofloxacin loaded chitosan biofilm might serve as a potential drug delivery system for wound healing applications.