Hardwiring wire-less networks: spatially encoded GPCR signaling in endocrine systems. (April 2019)

• Record Type: Journal Article
• Authors: Caengprasath, Natarin; Hanyaloglu, Aylin C
• Is Part Of: Current opinion in cell biology. Volume 57(2019)
• Page Start: 77
• Page End: 82
• Publication Date: 2019-04
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2018.12.009
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : The pivotal and diverse roles G protein-coupled receptors (GPCRs) play in physiology are matched by the increasingly complex signal systems they activate. Over the past decade, our models of GPCR signaling systems also include a vital role of location in controlling GPCR signaling, whereby plasma membrane, clathrin-associated structures and a diverse endomembrane network provide highly specialized signal platforms for this superfamily of receptors. The aim of this review is to highlight the recent developments in this fast-evolving field, with particular emphasis on endocrine-relevant GPCRs. We will also highlight studies that address the possibility of therapeutic intervention and how this fundamental cell biology can be translated to physiology/pathophysiology and therapeutic interventions.