Regulation of the Drosophila Imd pathway by signaling amyloids. (May 2019)

• Record Type: Journal Article
• Authors: Kleino, Anni; Silverman, Neal
• Is Part Of: Insect biochemistry and molecular biology. Volume 108(2019)
• Page Start: 16
• Page End: 23
• Publication Date: 2019-05
• Subjects: Drosophila immunity -- Imd signaling -- Functional amyloid; AMP antimicrobial peptide -- Atg1 Autophagy-related 1 -- DAI DNA-dependent activator of IFN-regulatory factors also known as ZBP-1 -- DAP meso-diaminopimelic acid -- DED Death effector domain -- Dredd death-related ced-3/Nedd2-like protein -- FADD Fas-associated protein with Death Domain -- Diap2 Drosophila inhibitor of apoptosis 2 -- IκB inhibitor of κB -- IKK IκB kinase -- Imd immune deficiency -- NF-κB Nuclear factor κB -- PGN peptidoglycan -- PGRP peptidoglycan recognition protein -- RHIM RIP homotypic interaction motif -- RIPK receptor-interacting protein kinase -- SMOC supramolecular organizing center -- Tab2 Tak1-associated binding protein 2 -- Tak1 TGF-β activated kinase 1 -- TRIF TIR-domain-containing adapter-inducing interferon-β; Insect biochemistry -- Periodicals; Insects -- Physiology -- Periodicals; Insects -- Molecular aspects -- Periodicals; Biochemistry -- Periodicals; Insectes -- Biochimie -- Périodiques; Insectes -- Composition -- Périodiques; Insectes -- Physiologie -- Périodiques; Insectes -- Aspect moléculaire -- Périodiques; Biochimie -- Périodiques; Biochemistry; Insect biochemistry; Insects -- Molecular aspects; Insects -- Physiology; Periodicals; 572.8157
• DOI: 10.1016/j.ibmb.2019.03.003
• Languages: English
• ISSNs: 0965-1748

Abstract

Abstract: Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso -diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex. Graphical abstract: Image 1 Highlights: In Drosophila, immune signaling through the Imd pathway is mediated by an amyloidal supramolecular organizing center (SMOC). Amyloid formation is dependent on cryptic RIP homotypic interaction motifs (cRHIMs) in PGRP-LC, PGRP-LE, and Imd. Post-translational modifications and Pirk regulate the disassembly of the amyloidal Imd SMOC.