Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. (May 2019)

• Record Type: Journal Article
• Authors: Kwon, Seungwon; Jin, Chul; Cho, Seung-Yeon; Park, Seong-Uk; Jung, Woo-Sang; Moon, Sang-Kwan; Park, Jung-Mi; Ko, Chang-Nam; Cho, Ki-Ho
• Is Part Of: Complementary therapies in clinical practice. Volume 35(2019)
• Page Start: 329
• Page End: 341
• Publication Date: 2019-05
• Subjects: Herbal medicine -- Meta-analysis -- Paeoniae Radix -- Restless legs syndrome -- Systematic review; Integrative medicine -- Periodicals; Integrative medicine -- Research -- Periodicals; Alternative medicine -- Periodicals; 615.5
• DOI: 10.1016/j.ctcp.2019.03.015
• Languages: English
• ISSNs: 1744-3881

Abstract

Abstract: Background and purpose: Paeoniae Radix has been used for legs discomfort such as restless legs syndrome. The aim of this review is to evaluate efficacy and safety of Paeoniae Radix-containing herbal medicine on restless legs syndrome. Methods: Literature search was conducted on PubMed, Scopus, CENTRAL, CiNii, KTKP, OASIS, and CNKI for randomized controlled trials that evaluated the effects of Paeoniae Radix-containing herbal medicines on restless legs syndrome. Results: Twelve studies (n = 639) were included. The overall methodological quality was low. In the herbal group, meta-analysis indicated statistically significant improvements in the total effective rate, the restless legs syndrome rating scale and the Pittsburgh Sleep Quality Index as compared with those in the non-herbal group. Herbal treatments were found to be relatively safe. Conclusion: Paeoniae Radix-containing herbal medicines might promote improvements in restless legs syndrome. However, we are unable to draw concrete conclusions owing to limitations of the included studies. Highlights: The aim of this review is to evaluate efficacy and safety of Paeoniae Radix-containing herbal medicine on RLS. Twelve studies (n = 639) were included in our meta-analysis. The overall methodological quality of these studies was low. Paeoniae Radix-containing herbal group revealed statistically significant improvements compared with non-herbal group. Treatments with Paeoniae Radix-containing herbal medicine may promote improvements in RLS without side effects. However, we are unable to draw concrete conclusions owing to limitations of the included studies.