Biocompatible and biodegradable inorganic nanostructures for nanomedicine: Silicon and black phosphorus. (April 2019)

• Record Type: Journal Article
• Authors: Qiu, Meng; Singh, Ajay; Wang, Dou; Qu, Junle; Swihart, Mark; Zhang, Han; Prasad, Paras N.
• Is Part Of: Nano today. Volume 25(2019)
• Page Start: 135
• Page End: 155
• Publication Date: 2019-04
• Subjects: BP black phosphorus -- FLBP few-layer black phosphorus -- Si silicon -- TMDs transition metal dichalcogenides -- QDs quantum dots -- NSs nanosheets -- NPs nanoparticles -- NIR near-infrared -- PTCE photothermal conversion efficiency -- PTT photothermal therapy -- PDT photodynamic therapy -- PS photosensitizer -- ROS reactive oxygen species -- EPR enhanced permeability and retention -- DDSs drug delivery systems -- MRI magnetic resonance imaging -- NMP n-methyl pyrrolidone -- DMSO dimethyl sulfoxide -- DMF dimethyl formamide -- IPA isopropyl alcohol -- CVD Chemical vapor deposition -- PSi porous silicon -- O2− superoxide anions -- CMC critical micelle concentration -- CTAB cetyltrimethly ammonium bromide -- MTT methyl thiazolyl tetrazolium -- CCK-8 Cell Counting Kit-8 -- TiL4 titanium sulfonate ligand -- RES reticuloendothelial system -- Mb myoglobin -- H2O2 hydrogen peroxide -- IgG immunoglobulin G -- IFE inner filter effect -- CEA carcino-embryonic -- FET field-effect transistor -- DOX doxorubicin -- FACS flow cytometry analysis -- PCPS polycation-functionalized nanoporous silicon -- RF radio frequency -- BBB blood-brain barrier -- NDs neurodegenerative disorders; Silicon -- Black phosphorus -- Nanomedicine -- Biocompatible -- Biodegradable; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2019.02.012
• Languages: English
• ISSNs: 1748-0132

Abstract

Graphical abstract: Highlights: The significance of silicon and black phosphorus nanomaterials in biomedical science is introduced. Fabrication, surface functionalization and properties of silicon and black phosphorus nanomaterials are addressed. Toxicity, biodistribution, elimination and bioavailability of silicon and black phosphorus nanomaterials are reviewed. Biomedical applications such as bioimaging, biosensing, nano-therapy and theraostics are discussed. Perspectives on the challenges and future prospects of silicon and black phosphorus nanomaterials are provided. Abstract: Nanomedicine has made great progress toward the diagnosis and treatment of diseases by exploiting physicochemical properties and biological interactions of nanomaterials that differ from the corresponding conventional materials. In the past decade, the advancement of biocompatible and biodegradable inorganic nanostructures has produced numerous nanomedicine platforms. Silicon and, more recently, black phosphorus (BP) offer promising nanoplatforms for bio-applications, including bioimaging, photo-therapy, drug delivery, combination therapy, and theranostics, due to their intrinsic unique properties, negligible elemental cytotoxicity, high drug-loading potential, long blood circulation time, and specific clearance pathways. In view of the growing importance of silicon and BP nanomaterials in the progress of nanomedicine, and their common feature characteristics as biodegradable biocompatible elemental semiconductors, this contribution reviews the latest advances in silicon and BP-based biomedical nanomaterials for disease diagnosis and therapy.