Effects of Bombyx mori nuclear polyhedrosis virus on serpin and antibacterial peptide expression in B. mori. (May 2019)

• Record Type: Journal Article
• Authors: Dong, Wei-tao; Ling, Xiao-dong; Xiao, Long-fei; Hu, Jun-jie; Zhao, Xing-xu; Liu, Ji-xing; Zhang, Yong
• Is Part Of: Microbial pathogenesis. Volume 130(2019)
• Page Start: 137
• Page End: 145
• Publication Date: 2019-05
• Subjects: Bombyx mori -- BmNPV -- Proteomics -- Serpins -- Antimicrobial peptides; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2019.02.035
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: The silkworm ( Bombyx mori ) is a typical and economically important lepidopteran species, and research has resulted in the development and accumulation of breeding lines. Studies of immune-related silkworm genes not only promote our understanding of silkworm immune response mechanisms, but they also inform insect immune molecular diversity research. Here, silkworm proteins were screened using proteomics after Bombyx mori nuclear polyhedrosis virus (BmNPV) infection, and 2368 silkworm proteins were identified, including six antimicrobial peptides and 12 serpins. The mRNA expression levels of these 18 proteins were examined at different times. The results indicated that attacin had the highest expression level, while serpin-5 and cecropin-D exhibited a negative regulatory correlation. These results provide a significant step toward a deeper understanding of B. mori immunoregulation. Graphical abstract: Image 1 Highlights: Expression of silkworm antimicrobial peptides and serpins varied during infection. Antimicrobial peptides and serpins were involved in immune defense against BmNPV. First report of a negative correlation between antimicrobial peptides.