Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis. Issue 5 (21st December 2018)

• Record Type: Journal Article
• Authors: Phi, Lan Thi Hanh; Sari, Ita Novita; Wijaya, Yoseph Toni; Kim, Kwang Seock; Park, Kichul; Cho, Art E.; Kwon, Hyog Young
• Is Part Of: IUBMB life. Volume 71:Issue 5(2019)
• Page Start: 601
• Page End: 610
• Publication Date: 2018-12-21
• Subjects: colorectal cancer -- ginsenoside Rd -- CSCs -- EMT; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.1984
• Languages: English
• ISSNs: 1521-6543

Abstract

ABSTRACT: Ginsenoside Rd is a saponin from ginseng and has been reported to have various biological activities. However, the effect of ginsenoside Rd on the metastasis of colorectal cancer (CRC) remains unknown. Here, we found that ginsenoside Rd decreased the colony‐forming ability, migration, invasion, and wound‐healing abilities of CRC cells, although it did not affect cell proliferation. In addition, using an inverse‐docking assay, we found that ginsenoside Rd bound to epidermal growth factor receptor (EGFR) with a high binding affinity, inducing the downregulation of stemness‐ and epithelial‐mesenchymal transition‐related genes; these were partially rescued by either exogenous EGF treatment or ectopic expression of SOX2. Furthermore, ginsenoside Rd significantly decreased the number and size of tumor metastasis nodules in the livers, lungs, and kidneys of mouse model of metastasis. © 2018 IUBMB Life, 71(5):601–610, 2019