Synthesis of heterobiaryls via Suzuki‐Miyaura coupling reaction of potassium aryltrifluoroborates with heteroaryl halides in aqueous systems. (18th February 2019)

• Record Type: Journal Article
• Authors: Liu, Leifang; Zhao, Kai; Li, Wenbo; Liu, Mingli; Chen, Yuting; Dong, Yan
• Is Part Of: Applied organometallic chemistry. Volume 33:Number 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-02-18
• Subjects: aqueous system -- heteroaryl halide -- heterobiaryl compound -- potassium aryltrifluoroborate -- Suzuki‐Miyaura coupling reaction; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.4831
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A variety of heterobiaryl compounds have been synthesized by the Suzuki‐Miyaura coupling reactions of heteroaryl halides with potassium aryltrifluoroborates. Pd (OAc)2 was found to be highly efficient for the Suzuki‐Miyaura coupling reactions of various heteroaryl halides with potassium aryltrifluoroborates in aqueous systems, delivering the corresponding heterobiaryl compounds in good to excellent yields. Abstract : A simple and highly efficient catalytic system has been developed for the synthesis of heterobiaryls via the Suzuki‐Miyaura couplings of potassium aryltrifluoroborates with heteroaryl halides using Pd (OAc)2 as catalyst in aqueous systems. A variety of heteroaryl halides could be coupled efficiently with potassium aryltrifluoroborates, delivering the desired heterobiaryls in good to excellent yields.