Myoepithelioma‐like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor‐positive cells: A case report. Issue 3 (9th February 2019)

• Record Type: Journal Article
• Authors: Kojima, Yui; Tanabe, Mikiko; Kato, Ikuma; Motoi, Toru; Kimura, Mariko; Sawazumi, Tomoe; Tanaka, Reiko; Chiba, Sawako; Otani, Masako; Inayama, Yoshiaki
• Is Part Of: Pathology international. Volume 69:Issue 3(2019)
• Page Start: 172
• Page End: 176
• Publication Date: 2019-02-09
• Subjects: estrogen receptor -- fluorescence in situ hybridization -- immunohistochemistry -- infiltrative growth -- INI1 -- myoepithelioma‐like tumor of the vulvar region -- SMARCB1; Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12765
• Languages: English
• ISSNs: 1320-5463

Abstract

Abstract : Recently, a new entity "myoepithelioma‐like tumor of the vulvar region (MELTVR)" was proposed as a rare mesenchymal neoplasm arising in vulvar regions of adult women. While MELTVRs morphologically resemble soft tissue myoepitheliomas and extraskeletal myxoid chondrosarcomas, they have a unique immunohistochemical profile (positive for epithelial membrane antigen and estrogen receptor, negative for S100 protein and glial fibrillary acidic protein, and loss of INI1/SMARCB1 expression), and lack EWSR1 and NR4A3 gene rearrangement, as seen by fluorescence in situ hybridization. MELTVRs are usually well‐demarcated tumors, with no reports of extensive infiltrative growth. In the current report, we present an unusual case of MELTVR showing infiltrative growth and harboring only a few estrogen receptor‐positive cells, which might indicate a variation in this rare tumor.