4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Sekelja, Monika; Paulsen, Jonas; Collas, Philippe
• Is Part Of: Genome biology. Volume 17:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-12
• Subjects: Genomes -- Periodicals; Biology -- Periodicals; Molecular biology -- Periodicals; 572.8633
• DOI: 10.1186/s13059-016-0923-2
• Languages: English
• ISSNs: 1474-760X

Abstract

Abstract Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data.