Factors associated with Anaplasma spp. seroprevalence among dogs in the United States. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: McMahan, Christopher; Wang, Dongmei; Beall, Melissa; Bowman, Dwight; Little, Susan; Pithua, Patrick; Sharp, Julia; Stich, Roger; Yabsley, Michael; Lund, Robert
• Is Part Of: Parasites & vectors. Volume 9:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-12
• Subjects: Anaplasma platys -- Canine anaplasmosis -- Seroprevalence -- Anaplasmaphagocytophilum -- Seroepidemiologic Studies -- Ticks -- United States -- Zoonoses; Parasitism -- Periodicals; Parasites -- Periodicals; Vector-pathogen relationships -- Periodicals; Animals as carriers of disease -- Periodicals; Insects as carriers of disease -- Periodicals; 616.96
• DOI: 10.1186/s13071-016-1431-7
• Languages: English
• ISSNs: 1756-3305

Abstract

Abstract Background Dogs in the United States are hosts to a diverse range of ticks and tick-borne pathogens, includingA. phagocytophilum, an important emerging canine and human pathogen. Previously, a Companion Animal Parasite Council (CAPC)-sponsored workshop proposed factors purported to be associated with the infection risk for tick-transmitted pathogens in dogs in the United States, including climate conditions, socioeconomic characteristics, local topography, and vector distribution. Methods Approximately four million test results from routine veterinary diagnostic tests from 2011–2013, which were collected on a county level across the contiguous United States, are statistically analyzed with the proposed factorsvia logistic regression and generalized estimating equations. Spatial prevalence maps of baselineAnaplasma spp. prevalence are constructed from Kriging and head-banging smoothing methods. Results All of the examined factors, with the exception of surface water coverage, were significantly associated withAnaplasma spp. prevalence. Overall, Anaplasma spp. prevalence increases with increasing precipitation and forestation coverage and decreases with increasing temperature, population density, relative humidity, and elevation. Interestingly, socioeconomic status and deer/vehicle collisions were positively and negatively correlated with canineAnaplasma seroprevalence, respectively. A spatial map of the canineAnaplasma hazard is an auxiliary product of the analysis.Anaplasma spp. prevalence is highest in New England and the Upper Midwest. Conclusions The results from the two posited statistical models (one that contains an endemic areas assumption and one that does not) are in general agreement, with the major difference being that the endemic areas model estimates a larger prevalence in Western Texas, New Mexico, and Colorado. AsA. phagocytophilum is zoonotic, the results of this analysis could also help predict areas of high risk for human exposure to this pathogen.