FRMD3 gene: its role in diabetic kidney disease. A narrative review. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Buffon, Marjoriê; Sortica, Denise; Gerchman, Fernando; Crispim, Daisy; Canani, Luís
• Is Part Of: Diabetology & metabolic syndrome. Volume 7:Issue 1(2015)
• Page Start: 1
• Page End: 10
• Publication Date: 2015-12
• Subjects: Diabetes -- Pathophysiology -- Periodicals; Metabolic syndrome -- Periodicals; 616.462005
• DOI: 10.1186/s13098-015-0114-4
• Languages: English
• ISSNs: 1758-5996

Abstract

Abstract Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. TheFRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located inFRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role ofFRMD3 in DKD.