Feasibility of deep learning for predicting live birth from a blastocyst image in patients classified by age. (1st March 2019)

• Record Type: Journal Article
• Authors: Miyagi, Yasunari; Habara, Toshihiro; Hirata, Rei; Hayashi, Nobuyoshi
• Is Part Of: Reproductive medicine and biology. Volume 18:Number 2(2019)
• Page Start: 190
• Page End: 203
• Publication Date: 2019-03-01
• Subjects: artificial intelligence -- blastocyst -- deep learning -- live birth -- neural network; Reproduction -- Periodicals; Reproductive health -- Periodicals; 612.6
• DOI: 10.1002/rmb2.12266
• Languages: English
• ISSNs: 1445-5781

Abstract

Abstract: Purpose: To identify artificial intelligence (AI) classifiers in images of blastocysts to predict the probability of achieving a live birth in patients classified by age. Results are compared to those obtained by conventional embryo (CE) evaluation. Methods: A total of 5691 blastocysts were retrospectively enrolled. Images captured 115 hours after insemination (or 139 hours if not yet large enough) were classified according to maternal age as follows: <35, 35‐37, 38‐39, 40‐41, and ≥42 years. The classifiers for each category and a classifier for all ages were related to convolutional neural networks associated with deep learning. Then, the live birth functions predicted by the AI and the multivariate logistic model functions predicted by CE were tested. The feasibility of the AI was investigated. Results: The accuracies of AI/CE for predicting live birth were 0.64/0.61, 0.71/0.70, 0.78/0.77, 0.81/0.83, 0.88/0.94, and 0.72/0.74 for the age categories <35, 35‐37, 38‐39, 40‐41, and ≥42 years and all ages, respectively. The sum value of the sensitivity and specificity revealed that AI performed better than CE ( P = 0.01). Conclusions: AI classifiers categorized by age can predict the probability of live birth from an image of the blastocyst and produced better results than were achieved using CE. Abstract : We made the AI classifiers of the deep learning with the convolutional neural networks from the image of the blastocyst categorized by age to predict the probability of achieving live birth. The AI classifiers categorized by age can predict live birth from the image of the blastocyst.