Bioreactors for Cardiac Tissue Engineering. Issue 7 (8th May 2018)

• Record Type: Journal Article
• Authors: Paez‐Mayorga, Jesus; Hernández‐Vargas, Gustavo; Ruiz‐Esparza, Guillermo U.; Iqbal, Hafiz M. N.; Wang, Xichi; Zhang, Yu Shrike; Parra‐Saldivar, Roberto; Khademhosseini, Ali
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 7(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-05-08
• Subjects: bioreactors -- cardiac diseases -- cardiac tissue engineering -- electrical stimulation -- mechanical stimulation -- tissue engineering -- vascularization; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201701504
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The advances in biotechnology, biomechanics, and biomaterials can be used to develop organ models that aim to accurately emulate their natural counterparts. Heart disease, one of the leading causes of death in modern society, has attracted particular attention in the field of tissue engineering. To avoid incorrect prognosis of patients suffering from heart disease, or from adverse consequences of classical therapeutic approaches, as well as to address the shortage of heart donors, new solutions are urgently needed. Biotechnological advances in cardiac tissue engineering from a bioreactor perspective, in which recapitulation of functional, biochemical, and physiological characteristics of the cardiac tissue can be used to recreate its natural microenvironment, are reviewed. Detailed examples of functional and preclinical applications of engineered cardiac constructs and the state‐of‐the‐art systems from a bioreactor perspective are provided. Finally, the current trends and future directions of the field for its translation to clinical settings are discussed. Abstract : Bioreactors for cardiac tissue engineering combine novel approaches from biology, engineering, biotechnology, biomechanics, and biomaterials to produce optimized tissue constructs that biomimic challenging cardiovascular diseases. This review first addresses functional and preclinical applications of engineered cardiac constructs and the state‐of‐the‐art systems from a bioreactor perspective and then emphasizes their practical usefulness, trends, future directions, and translation to clinical settings.