Risk of mycobacterial disease among cancer patients: A population-based cohort study in a TB endemic area. (April 2019)

• Record Type: Journal Article
• Authors: Chen, Yi-Ming; Lin, Ching-Heng; Chen, Hsin-Hua; Chao, Wen-Cheng; Chen, Der-Yuan; Lin, Che-Chen; Liao, Tsai-Ling
• Is Part Of: Cancer epidemiology. Volume 59(2019:Apr.)
• Page Start: 64
• Page End: 70
• Publication Date: 2019-04
• Subjects: Tuberculosis -- Nontuberculous mycobacterial disease -- Risk factor -- Cancer; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2019.01.010
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Among the cancer patients, the risk of occurring NTM disease was higher than TB. Younger hematological cancer patients had a higher risk for NTM disease development. Elevated risk of NTM disease occurred until more than 1 year after cancer diagnosis. A 4.09-fold increased risk of TB within 6 months after cancer diagnosis in patients compared to those without cancer. Advanced age and being male were risk factors for developing TB disease. Abstract: Objectives: Tuberculosis (TB) and nontuberculous mycobacteria (NTM) disease have similar symptoms, which makes them difficult to distinguish clinically and leads to the danger of NTM disease being neglected. The aim of this study was to assess the risk of developing mycobacterial disease among cancer patients. Methods: We conducted a retrospective cohort study using a population-based database. The multivariable Cox proportional hazards model was adjusted to identify independent factors contributing to the development of mycobacterial disease in the cancer cohort. Results: The results showed that the increased risk of developing TB and NTM disease was 1.84-fold and 4.43-fold, respectively, in cancer patients compared with the general population. Advanced age (≥65years) and being male were risk factors for developing TB disease. There was a 4.09-fold significantly increased risk of TB disease within six months of a cancer diagnosis. Hematological cancer patients were most likely to develop mycobacterial disease. Younger hematological cancer patients (< 45years) had a higher risk of NTM disease development. Conclusion: There is an increasing risk of mycobacterial disease in cancer patients. We suggest that the possibility of mycobacterial disease in cancer patients should be assessed during the period of cancer therapy, particularly in those who have risk factors.