Bloodstream infections in patients with malignancies: implications for antibiotic treatment in a Ghanaian tertiary setting. (December 2015)

• Record Type: Journal Article
• Authors: Obeng-Nkrumah, Noah; Labi, Appiah-Korang; Acquah, Michael; Donkor, Eric
• Is Part Of: BMC research notes. Volume 8:Number 1(2015)
• Page Start: 1
• Page End: 10
• Publication Date: 2015-12
• Subjects: Ghana -- Cancer -- Blood stream -- Infections -- Bacteria -- Fungi -- Multidrug -- Resistant; Medicine -- Periodicals; Biology -- Periodicals; 610.5
• DOI: 10.1186/s13104-015-1701-z
• Languages: English
• ISSNs: 1756-0500

Abstract

Abstract Background Bloodstream infections (BSI) remain a major cause of mortality in patients with malignancies. We present the first report on the microbiological profile of bacteraemia and fungaemia among cancer patients in Ghana. Methods From January 2010 through December 2013, we retrospectively analyzed the spectrum of bloodstream pathogens in cancer patients from Korle-Bu Teaching Hospital, Ghana—focusing on multidrug resistant isolates (MDRs). Results Overall BSI were confirmed in 22 % (n = 93/453) of total blood cultures. Our data highlights a co-dominance of Gram-negative (n = 49/93, 52.6 %) and Gram-positive (n = 40/93, 43.0 %) bacteria with the former less likely to infect children than adults [odds ratio (OR), 0.56; 95 % confidence interval (CI) 0.14–0.91;p value = 0.027]. Staphylococcus epidermidis was the most isolated bacteria (30.1 %; n = 28/93). About 61 % (n = 25/41) ofEnterobacteriaceae isolates were resistant to cefotaxime; a majority (n = 24/25, 96 %) of which were MDRs and mostly susceptible to amikacin and levofloxacin. Four (80 %) penicillin resistant streptococci were found; 2 of which were MDRs and sensitive to erythromycin and cefuroxime. Methicillin resistantStaphylococcus aureus and vancomycin resistant enterococci were not identified. In multivariate analysis, theEnterobacteriaceae compared to other organisms were significantly associated with multidrug resistance (adjusted OR, 33.6; 95 % CI 6.41–88.73; p value 0.001). Conclusion MDRs, especially cefotaxime resistantEnterobacteriaceae, are common among patients with cancer in our institution but vary among different patient populations. The results show that empiric antibiotic treatment for cancer patients cannot be done effectively without regard for selective antimicrobial use based on local epidemiologic data.