Amyloid A amyloidosis secondary to avian tuberculosis in naturally infected domestic pekin ducks (Anas platyrhynchos domestica). (April 2019)

• Record Type: Journal Article
• Authors: Chen, Hongxi; Zhu, Dekang; Wang, Mingshu; Jia, Renyong; Chen, Shun; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Liu, Yunya; Zhang, Ling; Yu, Yanling; Chen, Xiaoyue; Cheng, Anchun
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 63(2019)
• Page Start: 136
• Page End: 141
• Publication Date: 2019-04
• Subjects: MAA Mycobacterium. avium subsp. avium -- AA amyloidosis Amyloid A amyloidosis -- qRT-PCR quantitative real-time RT-PCR; Avian tuberculosis -- AA amyloidosis -- Congo red staining -- Potassium permanganate-congo red staining -- qRT-PCR; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2019.01.016
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: This is the first report for amyloid A amyloidosis secondary to avian tuberculosis in naturally infected Pekin ducks. The liver, lung and others organs of M. avium subsp. avium infected Pekin ducks exhibited amyloid proteins was AA amyloidosis. The expression level of IL-1β, IL-6, IL-10, TNF-α and SAA2 of M. avium subsp. avium infected ducks increased from 4 to 43. Abstract: To investigate the correlation between avian tuberculosis and duck amyloidosis, the liver, lung, spleen, kidney, duodenum and pectoralis muscle of ducks naturally infected with Mycobacterium avium subsp . avium were used to detect amyloidosis by Congo red staining and potassium permanganate-Congo red staining. The expression level of IL-1β, IL-6, IL-10, TNF-α and SAA2 were detected by quantitative real-time RT-PCR (qRT-PCR). The results showed that the liver, lung, spleen, kidney, duodenum and pectoralis muscle of the infected ducks exhibited amyloid proteins under ordinary light microscopy and the polarization light under polarized light microscopy. However, no amyloid deposition in potassium permanganate-Congo red staining sections indicated that the amyloidosis was AA amyloidosis. In addition, the expression level of IL-1β, IL-6, IL-10, TNF-α and SAA2 increased from 4 to 43. This study showed that avian tuberculosis could induce secondary amyloidosis in naturally infected ducks.