Deficits of visuospatial working memory and executive function in single- versus multiple-domain amnestic mild cognitive impairment: A combined ERP and sLORETA study. Issue 5 (May 2019)

• Record Type: Journal Article
• Authors: Gu, Lihua; Chen, Jiu; Gao, Lijuan; Shu, Hao; Wang, Zan; Liu, Duan; Yan, Yanna; Li, Shijiang; Zhang, Zhijun
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 5(2019:May)
• Page Start: 739
• Page End: 751
• Publication Date: 2019-05
• Subjects: Event-related potential -- Go/Nogo -- Multiple-domain amnestic mild cognitive impairment -- Single-domain amnestic mild cognitive impairment -- Visuospatial working memory; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.01.025
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Md-aMCI showed reduced P300 amplitudes, compared to sd-aMCI during VSWM task. Md-aMCI showed reduced N200 amplitudes, compared to sd-aMCI during Go/Nogo task. ERP and sLORETA during VSWM and Go/Nogo enabled distinguishing md-aMCI from sd-aMCI. Abstract: Objective: According to recent criteria of classification, amnestic mild cognitive impairment (aMCI) could be divided into two categories: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The difference between sd-aMCI and md-aMCI needs further exploration. The present study aimed to compare deficits in visuospatial working memory (VSWM) and executive function between sd-aMCI versus md-aMCI patients by use of event-related potentials (ERP) and standardized low-resolution brain electromagnetic tomography analysis (sLORETA). Methods: The ERP data were measured and analyzed in 26 sd-aMCI, 13 md-aMCI patients and 46 healthy elderly controls (HEC) during VSWM and Go/Nogo processes. Results: During VSWM task, md-aMCI patients showed decreased P300 amplitude compared to HEC and sd-aMCI patients (All p < 0.05). As compared to sd-aMCI, md-aMCI showed a hypoactivation in the right middle frontal gyrus in 1-back task during the P300 time range. During the Go/Nogo task, sd-aMCI and md-aMCI patients showed reduced N200 amplitude, compared to HEC (All p < 0.05). However, md-aMCI patients had decreased N200 amplitude, with respect to sd-aMCI patients. Further, as compared to sd-aMCI patients, md-aMCI patients showed a hypoactivation in the right superior frontal gyrus during the N200 time range. Conclusions: These findings with a combined ERP and sLORETA study showed more severe deficits in updating operations of WM, detections of the target stimulus and conflict processes in md-aMCI, compared to sd-aMCI patients. Significance: The present study showed that a combined ERP and sLORETA study during the VSWM and Go/Nogo tasks could distinguish md-aMCI from sd-aMCI.