Different patterns of movement-related cortical oscillations in patients with myoclonus and in patients with spinocerebellar ataxia. Issue 5 (May 2019)

• Record Type: Journal Article
• Authors: Visani, E.; Mariotti, C.; Nanetti, L.; Mongelli, A.; Castaldo, A.; Panzica, F.; Franceschetti, S.; Canafoglia, L.
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 5(2019:May)
• Page Start: 714
• Page End: 721
• Publication Date: 2019-05
• Subjects: ERD/ERS analysis -- Myoclonus -- EPM1 -- Ataxia -- SCA; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.01.021
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: EEG oscillations related to Go/No-go tasks are distinctive in patients with myoclonus or ataxia. Patients with myoclonus show abnormal desynchronization/synchronization due to defective inhibition. Patients with ataxia show a defect in the lateralization of the desynchronization. Abstract: Objective: To assess whether different patterns of EEG rhythms during a Go/No-go motor task characterize patients with cortical myoclonus (EPM1) or with spinocerebellar ataxia (SCA). Methods: We analyzed event-related desynchronization (ERD) and synchronization (ERS) in the alpha and beta-bands during visually cued Go/No-go task in 22 patients (11 with EPM1, 11 with SCA) and 11 controls. Results: In the Go condition, the only significant difference was a reduced contralateral beta-ERS in the EPM1 patients compared with controls; in the No-go condition, the EPM1 patients showed prolonged alpha-ERD in comparison with both controls and SCA patients, and reduced or delayed alpha- and beta-ERS in comparison with controls. In both conditions, the SCA patients, unlike EPM1 patients and controls, showed minimal or absent lateralization of alpha- and beta-ERD. Conclusions: EPM1 patients showed abnormal ERD/ERS dynamics, whereas SCA patients mainly showed defective ERD lateralization. Significance: A different behavior of ERS/ERD distinguished the two patient groups: the pattern observed in EPM1 suggests a prominent defect of inhibition occurring in motor cortex contralateral to activated segment, whereas the pattern observed in SCA suggested a defective lateralization attributable to the damage of cerebello-cortical network, which is instead marginal in patients with cortical myoclonus.