Preparation of zinc layered hydroxide-ferulate and coated zinc layered hydroxide-ferulate nanocomposites for controlled release of ferulic acid. (7th June 2019)

• Record Type: Journal Article
• Authors: Hashim, Norhayati; Sharif, Sharifah Norain Mohd; Muda, Zuhailimuna; Md Isa, Illyas; Ali, Noorshida Mohd; Bakar, Suriani Abu; Sidik, Siti Munirah; Hussein, Mohd Zobir
• Is Part Of: Materials research innovations. Volume 23:Number 4(2019)
• Page Start: 233
• Page End: 245
• Publication Date: 2019-06-07
• Subjects: Nanocomposite -- zinc layered hydroxide -- ferulic acid -- direct reaction method -- controlled release; Materials -- Research -- Periodicals; Matériaux -- Recherche -- Périodiques; 620.1105
• DOI: 10.1080/14328917.2018.1444696
• Languages: English
• ISSNs: 1432-8917

Abstract

Abstract: Ferulic acid (FA) was intercalated into zinc layered hydroxide (ZLH) to form a new nanocomposite, namely zinc layered hydroxide-ferulate (ZLH-FA) and was further coated by surfactants sodium dodecyl sulfate (SDS) and polysorbate 80 (Tween-80). XRD patterns of the ZLH-FA nanocomposite obtained reveals a crystalline structure with basal spacing of 26·9 Å. The XRD pattern of the coated nanocomposite showed similar peaks to the ZLH-FA nanocomposite. The loading of FA in the nanocomposite was estimated to be 56·82% (w/w), and its thermal stability was markedly enhanced compare to its free counterpart. A controlled release study showed that the FA was release was slower from interlayer of ZLH-FA/SDS and ZLH-FA/Tween-80 nanocomposites compared to the ZLH-FA nanocomposite. The mechanism of release follow the pseudo-second order kinetics model for all nanocomposites. Results from this study highlight the potential of these nanocomposites for controlled release formulation of FA drug anion.