A novel cause for primordial dwarfism revealed: defective tRNA modification. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Filonava, Liudmila; Torres, Adrian; de Pouplana, Lluis
• Is Part Of: Genome biology. Volume 16:Issue 1(2015)
• Page Start: 1
• Page End: 2
• Publication Date: 2015-12
• Subjects: Genomes -- Periodicals; Biology -- Periodicals; Molecular biology -- Periodicals; 572.8633
• DOI: 10.1186/s13059-015-0786-y
• Languages: English
• ISSNs: 1474-760X

Abstract

Abstract A mutation in theWDR4 gene, coding for a tRNA-modifying enzyme, leads to reduced levels of guanosine methylation in tRNA in patients with primordial dwarfism. See related Research article:http://www.genomebiology.com/2015/16/1/210 .