Microphthalmia With Multiple Anterior Segment Defects in Portuguese Water Dogs. Issue 2 (March 2019)

• Record Type: Journal Article
• Authors: Shaw, Gillian C.; Tse, May P. Y.; Miller, Andrew D.
• Is Part Of: Veterinary pathology. Volume 56:Issue 2(2019)
• Page Start: 269
• Page End: 273
• Publication Date: 2019-03
• Subjects: Portuguese Water Dog -- microphthalmia -- anterior segment dysgenesis -- cataract -- uvea -- Descemet's membrane -- congenital abnormalities -- eye; Veterinary pathology -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1177/0300985818794248
• Languages: English
• ISSNs: 0300-9858

Abstract

Portuguese Water Dog breeders and veterinary ophthalmologists recognize microphthalmia with multiple congenital ocular anomalies. Fifteen Portuguese Water Dog puppies (<8 weeks of age; 8 females, 7 males) and 1 adult (5 years old; castrated male) with microphthalmia were examined. The 2 most common abnormalities were microphthalmia (31/32 eyes; 97%) and lens abnormality (congenital cataract or aphakia; 32/32 eyes; 100%). Other common histologic lesions included lack of both a ciliary cleft and trabecular meshwork (15/32 eyes; 47%) and abnormal relationship of anterior segment structures (15/32 eyes; 47%). Many of the observed lesions were similar to those described in various types of anterior segment dysgenesis in humans. Our findings define the histologic lesions in affected Portuguese Water Dogs and suggest a genetic defect that causes anterior segment malformation early in development.