A new phenanthrene dimer from Dendrobium palpebrae. Issue 4 (3rd April 2019)

• Record Type: Journal Article
• Authors: Kyokong, Napat; Muangnoi, Chawanphat; Thaweesest, Wuttinont; Kongkatitham, Virunh; Likhitwitayawuid, Kittisak; Rojsitthisak, Pornchai; Sritularak, Boonchoo
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 4(2019)
• Page Start: 391
• Page End: 397
• Publication Date: 2019-04-03
• Subjects: Dendrobium palpebrae -- Orchidaceae -- antioxidant -- phenanthrene dimer -- dendroflorin; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1429416
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new phenanthrene dimer, namely dendropalpebrone (1 ), was isolated from the whole plant of Dendrobium palpebre, along with nine known compounds (2–10 ). All of the isolates were evaluated for their hydroxyl radical scavenging effects using a deoxyribose assay. Dendroflorin (10 ) showed an appreciable activity, and therefore was selected for further studied in RAW264.7 cells. Compound10 significantly decreased ROS in H2 O2 -stimulated RAW264.7 cells in a dose-dependent manner, and improved activity of SOD, GPx, and CAT enzymes. Abstract :