Genetic Polymorphism in RANK is Associated with Mandibular Size. (September 2018)

• Record Type: Journal Article
• Authors: Küchler, Erika Calvano; Nascimento, Mariele Andrade do; Matsumoto, Mirian Aiko Nakane; Romano, Fabio Lourenço; da Silva, Raquel Assed Bezerra; Ayumi Omori, Marjorie; Antunes, Lívia Azeredo; Antunes, Leonardo Santos; da Silva, Léa Assed Bezerra; Nelson-Filho, Paulo
• Is Part Of: Journal of orthodontics. Volume 45:Number 3(2018)
• Page Start: 157
• Page End: 162
• Publication Date: 2018-09
• Subjects: Gene -- polymorphisms -- mandible and maxilla; Orthodontics -- Periodicals; 617.643005
• DOI: 10.1080/14653125.2018.1476018
• Languages: English
• ISSNs: 1465-3125

Abstract

Objective: The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans. Design: DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM–A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism. Setting: School of Dentistry of Ribeirão Preto, University of São Paulo. Participants: A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study. Results: The polymorphism in RANK was associated with a higher Go-Pg measurement ( p = .039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg ( p = .017) and Co-Gn ( p = .043). Conclusion: The polymorphism rs3826620 in RANK is associated with the mandibular size.