Beyond the Discovery Void: New Targets for Antibacterial Compounds. (June 2016)

• Record Type: Journal Article
• Authors: Broughton, Claire E.; Van Den Berg, Hugo A.; Wemyss, Alan M.; Roper, David I.; Rodger, Alison
• Is Part Of: Science progress. Volume 99:Number 2(2016)
• Page Start: 153
• Page End: 182
• Publication Date: 2016-06
• Subjects: antibiotics -- bacterial resistances to antibiotics -- MRSA -- discovery void -- cell wall -- cell division; Science -- Periodicals; Research; Science; Science; Electronic journals; Periodicals; Periodicals; 505
• DOI: 10.3184/003685016X14616130512308
• Languages: English
• ISSNs: 0036-8504

Abstract

Antibiotics save many lives, but their efficacy is under threat: overprescription, population growth, and global travel all contribute to the rapid origination and spread of resistant strains. Exacerbating this threat is the fact that no new major classes of antibiotics have been discovered in the last 30 years: this is the "discovery void." We discuss the traditional molecular targets of antibiotics as well as putative novel targets.