A Bayesian approach to distinguishing interdigitated tongue muscles from limited diffusion magnetic resonance imaging. (October 2015)

• Record Type: Journal Article
• Authors: Ye, Chuyang; Murano, Emi; Stone, Maureen; Prince, Jerry L.
• Is Part Of: Computerized medical imaging and graphics. Volume 45(2015)
• Page Start: 63
• Page End: 74
• Publication Date: 2015-10
• Subjects: C13; Diffusion magnetic resonance imaging -- Limited gradient directions -- Sparse reconstruction -- Prior directional knowledge -- Interdigitated tongue muscles; Diagnostic imaging -- Periodicals; Imaging systems in medicine -- Periodicals; Diagnosis, Radioscopic -- Data processing -- Periodicals; Diagnostic Imaging -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Diagnostic imaging; Periodicals; Electronic journals; Electronic journals; 616.0754
• DOI: 10.1016/j.compmedimag.2015.07.005
• Languages: English
• ISSNs: 0895-6111

Abstract

Abstract : Highlights: We resolve crossing tongue muscles with limited diffusion gradient directions. We use prior direction knowledge and formulate the problem in an MAP framework. Fiber directions are estimated using a noise-aware weighted L1-norm minimization. The method reduces the effect of noise and resolves crossing fibers. The method was applied on patients to show its potential for clinical use. Abstract: The tongue is a critical organ for a variety of functions, including swallowing, respiration, and speech. It contains intrinsic and extrinsic muscles that play an important role in changing its shape and position. Diffusion tensor imaging (DTI) has been used to reconstruct tongue muscle fiber tracts. However, previous studies have been unable to reconstruct the crossing fibers that occur where the tongue muscles interdigitate, which is a large percentage of the tongue volume. To resolve crossing fibers, multi-tensor models on DTI and more advanced imaging modalities, such as high angular resolution diffusion imaging (HARDI) and diffusion spectrum imaging (DSI), have been proposed. However, because of the involuntary nature of swallowing, there is insufficient time to acquire a sufficient number of diffusion gradient directions to resolve crossing fibers while the in vivo tongue is in a fixed position. In this work, we address the challenge of distinguishing interdigitated tongue muscles from limited diffusion magnetic resonance imaging by using a multi-tensor model with a fixed tensor basis and incorporating prior directional knowledge. The prior directional knowledge provides information on likely fiber directions at each voxel, and is computed with anatomical knowledge of tongue muscles. The fiber directions are estimated within a maximum a posteriori (MAP) framework, and the resulting objective function is solved using a noise-aware weighted ℓ1 -norm minimization algorithm. Experiments were performed on a digital crossing phantom and in vivo tongue diffusion data including three control subjects and four patients with glossectomies. On the digital phantom, effects of parameters, noise, and prior direction accuracy were studied, and parameter settings for real data were determined. The results on the in vivo data demonstrate that the proposed method is able to resolve interdigitated tongue muscles with limited gradient directions. The distributions of the computed fiber directions in both the controls and the patients were also compared, suggesting a potential clinical use for this imaging and image analysis methodology.