Fe2+‐Responsive Bimodal MRI and Fluorescent Imaging Probe Based on a Gadolinium(III) Complex. Issue 19 (9th June 2015)

• Record Type: Journal Article
• Authors: Luo, Jian; Zhu, Xiao‐Feng; Chen, Zhong‐Ning
• Is Part Of: European journal of inorganic chemistry. Issue 19(2015)
• Page Start: 3087
• Page End: 3093
• Publication Date: 2015-06-09
• Subjects: Fluorescent probes -- Imaging ­agents -- Magnetic resonance imaging -- Gadolinium -- Iron; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201500411
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract: An Fe 2+ ‐responsive bimodal MRI and fluorescent imaging probe, Gd‐DTTA‐BPP (DTTA = diethylenetriamine‐ N, N, N″, N″ ‐tetraacetate, BPP = 2‐{4‐[(2, 2′‐bipyridin)‐5‐ylethynyl]phenoxy}‐ N ‐ethylacetamide), has been synthesized and characterized and its relaxivity and fluorescence properties examined. Gd‐DTTA‐BPP displays a high relaxation efficiency (10.3 mM –1 s –1 at 23 MHz and 25 °C) as a result of its rigid ligand and two inner‐sphere water molecules ( q = 2). In the presence of 1.0 equiv. Fe 2+, the relaxation efficiency increased from 10.3 to 13.6 mM –1 s –1 (23 MHz and 25 °C) due to the complexation of Gd‐DTTA‐BPP with Fe 2+ . The fluorescence emission of the Gd‐DTTA‐BPP complex is quenched by Fe 2+ ions. The confocal fluorescence imaging experiments on living cells showed that the imaging probe is permeable to living cells and localizes in the cytoplasm. Abstract : An Fe 2+ ‐responsive bimodal MRI and fluorescent imaging agent based on the gadolinium(III) complex Gd‐DTTA‐BPP exhibits clearly enhanced relaxivity and significant turn‐off luminescence in response to Fe 2+ .