Animal models of multiple sclerosis: From rodents to zebrafish. (March 2019)

• Record Type: Journal Article
• Authors: Burrows, David John; McGown, Alexander; Jain, Saurabh A; De Felice, Milena; Ramesh, Tennore M; Sharrack, Basil; Majid, Arshad
• Is Part Of: Multiple sclerosis. Volume 25:Number 3(2019)
• Page Start: 306
• Page End: 324
• Publication Date: 2019-03
• Subjects: Multiple sclerosis -- experimental autoimmune encephalomyelitis -- animal models -- zebrafish -- demyelination; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458518805246
• Languages: English
• ISSNs: 1352-4585

Abstract

Multiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system. Animal models of MS have been critical for elucidating MS pathological mechanisms and how they may be targeted for therapeutic intervention. Here we review the most commonly used animal models of MS. Although these animal models cannot fully replicate the MS disease course, a number of models have been developed to recapitulate certain stages. Experimental autoimmune encephalomyelitis (EAE) has been used to explore neuroinflammatory mechanisms and toxin-induced demyelinating models to further our understanding of oligodendrocyte biology, demyelination and remyelination. Zebrafish models of MS are emerging as a useful research tool to validate potential therapeutic candidates due to their rapid development and amenability to genetic manipulation.