Insights into microbiome research 5: Mapping is first but function must come next. (February 2019)

• Record Type: Journal Article
• Authors: Baranzini, Sergio E
• Is Part Of: Multiple sclerosis. Volume 25:Number 2(2019)
• Page Start: 193
• Page End: 195
• Publication Date: 2019-02
• Subjects: Multiple sclerosis -- microbiome -- mapping; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458518811203
• Languages: English
• ISSNs: 1352-4585

Abstract

Several efforts identifying differential bacterial prevalence in the gut of multiple sclerosis (MS) patients have been reported and many more are underway. While these are critical first steps in determining the involvement of gut microbes in MS pathogenesis, functional assays (both in vitro and in vivo) are needed to explore the mechanisms underlying the observed changes and ultimately implementing interventional strategies to counter severity, progression or even reduce the chance that it develops in the first place.