Ursolic acid promotes the apoptosis of cervical cancer cells by regulating endoplasmic reticulum stress. Issue 4 (10th January 2019)

• Record Type: Journal Article
• Authors: Guo, Jin‐Ling; Han, Teng; Bao, Le; Li, Xiao‐Mei; Ma, Jing‐Quan; Tang, Li‐Ping
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 45:Issue 4(2019)
• Page Start: 877
• Page End: 881
• Publication Date: 2019-01-10
• Subjects: apoptosis -- C/EBP homologous protein -- endoplasmic reticulum stress -- ursolic acid; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.13919
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Aim: Ursolic acid is a triterpenoid common in plants and exhibits anti‐carcinogenic activity. This study aimed to reveal the role of endoplasmic reticulum stress in cervical cancer cell apoptosis promoted by ursolic acid. Methods: HeLa cells were treated with ursolic acid or/and 4‐phenylbutyric acid. The viability and apoptosis of HeLa cells were evaluated by MTT assay and flow cytometry, respectively. Results: Ursolic acid decreased HeLa cell viability in a time‐ and dose‐ dependent manner, and induced HeLa cell apoptosis in a dose‐dependent manner. Moreover, ursolic acid increased the expression of C/EBP homologous protein and glucose‐regulated protein 78 at protein levels, while 4‐phenylbutyric acid antagonized the apoptosis of HeLa cells induced by ursolic acid. Conclusion: Ursolic acid inhibits the viability and promotes the apoptosis of HeLa cells. Endoplasmic reticulum stress may mediate the apoptosis of cervical cancer cells stimulated by ursolic acid.