Effects of preoperative hepatitis B virus infection, hepatitis C virus infection, and coinfection on the development of new‐onset diabetes after kidney transplantation. Issue 5 (14th October 2018)

• Record Type: Journal Article
• Authors: Liang, Jing; Lv, Chaoyang; Chen, Minling; Xu, Ming; Zhao, Chenhe; Yang, Yinqiu; Wang, Jina; Zhu, Dong; Gao, Jian; Rong, Ruiming; Zhu, Tongyu; Yu, Mingxiang
• Is Part Of: Journal of diabetes. Volume 11:Issue 5(2019)
• Page Start: 370
• Page End: 378
• Publication Date: 2018-10-14
• Subjects: diabetes mellitus -- hepatitis B virus -- hepatitis C virus -- kidney transplantation; 糖尿病 -- 乙肝病毒 -- 丙肝病毒 -- 肾移植; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12853
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: The effects of preoperative hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and HBV plus HCV coinfection on the development of new‐onset diabetes after transplantation (NODAT) remain unexplored in kidney transplant recipients (KTRs). This study examined the association between preoperative viral status (i.e., HBV, HCV, and HBC + HCV infection) and incident NODAT in a large population of Chinese KTRs. Methods: This population‐based retrospective cohort study enrolled 557 subjects who underwent kidney transplantation between 1993 and 2014 at Zhongshan Hospital. Pre‐, peri‐, and postoperative data were extracted and analyzed. Viral status was defined by serological results for hepatitis B surface antigen and anti‐HCV antibody. The cumulative incidence of NODAT was compared across four groups of KTRs with different viral status. Multivariate Cox regression models were used to estimate the effects of HBV, HCV, and HBC + HCV infection on incident NODAT after adjusting for important confounders. Results: Patients seropositive for HCV (both HCV monoinfection and HBC + HCV coinfection) had a significantly higher cumulative incidence of NODAT than KTRs who were not infected with HCV ( P < 0.05 for both). However, only HCV infection alone was found to be a risk factor for NODAT, increasing the NODAT risk 3.03‐fold (95% confidence interval 1.77‐5.18; P < 0.001). There was no independent correlation between HBV infection (alone or combined with HCV) and incident NODAT in KTRs. Conclusions: Preoperative HCV infection significantly increased the risk of NODAT in Chinese KTRs, whereas HBV infection and HBC + HCV coinfection were not correlated with NODAT development. Abstract : Highlights A retrospective cohort study of preoperative hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and HBV and HCV coinfection was conducted to determine their effects on new‐onset diabetes after transplantation (NODAT) among Chinese kidney transplant recipients (KTRs). Preoperative HCV infection was significantly correlated with the risk of NODAT. Preoperative HBV and HBV plus HCV coinfection did not independently increase the risk of NODAT.