Not all clots are created equal: a review of deficient thrombolysis with tissue plasminogen activator (tPA) in patients with metabolic syndrome. (3rd June 2019)

• Record Type: Journal Article
• Authors: Mosimah, Charles I.; Murray, Pamela J.; Simpkins, James W.
• Is Part Of: International journal of neuroscience. Volume 129:Number 6(2019)
• Page Start: 612
• Page End: 618
• Publication Date: 2019-06-03
• Subjects: Metabolic syndrome -- ischemic stroke -- tissue plasminogen activator -- thrombolysis -- cardiovascular disease; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2018.1550400
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract: Metabolic syndrome is a cluster of cardiovascular risk factors associated with a prothrombotic, proinflammatory and hypofibrinolysis state. Although resistance to tissue plasminogen activator (tPA) in metabolic syndrome patients has been associated with a defective fibrinolytic system, the factors and mechanisms underlining such resistance is unclear. While there is a great debate on proposed mechanisms, fundamental questions regarding resistance to tPA in metabolic syndrome patients with ischemic stroke remain unanswered. This article reviews articles and documents published between 2001 and 2017, and provides an overview of metabolic syndrome, factors associated with tPA resistance in metabolic syndrome, conflicting evidence of insufficient dosing of tPA in overweight/obese patients and future directions for research.