Summer season induced heat stress impact on the expression patterns of different toll-like receptor genes in Malabari goats. Issue 3 (4th May 2019)

• Record Type: Journal Article
• Authors: Vandana, G. D.; Bagath, M.; Sejian, V.; Krishnan, G.; Beena, V.; Bhatta, R.
• Is Part Of: Biological rhythm research. Volume 50:Issue 3(2019)
• Page Start: 466
• Page End: 482
• Publication Date: 2019-05-04
• Subjects: Climate change -- goat -- heat stress -- immune response -- TLRs; Biological rhythms -- Periodicals; Chronobiology -- Periodicals; Cycles -- Periodicals; Biological Clocks; Chronobiology; Circadian Rhythm; 570
• DOI: 10.1080/09291016.2018.1464638
• Languages: English
• ISSNs: 0929-1016

Abstract

Abstract: The study was conducted with the primary objective of establishing the impact of heat stress on the expression pattern of different toll-like-receptors (TLRs) in Malabari goats. The study was conducted for a period of 45 days using twelve Malabari goats. The goats were randomly allocated into two groups: MC ( n = 6; Malabari control) and MHS ( n = 6; Malabari heat stress). At the end of study, all 12 animals were slaughtered and their mesenteric lymph node (MLN) tissues were collected for gene expression. Heat stress significantly ( p < 0.05) down regulated TLR1, TLR4, TLR5 and TLR6 and significantly increased ( p < 0.05) TLR2 expression pattern. A negative correlation ( p < 0.01) was also established between THI and different TLRs except TLR3, TLR7 and TLR10. The study indicated that TLR2 could serve as ideal immunological marker for establishing the superior thermo-tolerance ability of Malabari breed in terms of maintaining the immune status during heat stress challenges.