Hepatitis A virus vaccination in childhood-onset systemic lupus erythematosus. (February 2019)

• Record Type: Journal Article
• Authors: Mertoglu, S; Sahin, S; Beser, O F; Adrovic, A; Barut, K; Yuksel, P; Sazak, S; Kocazeybek, B S; Kasapcopur, O
• Is Part Of: Lupus. Volume 28:Number 2(2019)
• Page Start: 234
• Page End: 240
• Publication Date: 2019-02
• Subjects: Anti-HAV -- childhood-onset systemic lupus erythematosus -- efficacy -- hepatitis A virus vaccination -- safety; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203318819827
• Languages: English
• ISSNs: 0961-2033

Abstract

Objectives: Vaccination of systemic lupus erythematosus patients with non-live vaccines may decrease vaccine-preventable infections and mortalities. In the present study, we aimed to compare the immunogenicity and safety of inactivated hepatitis A vaccination in childhood-onset systemic lupus erythematosus and healthy subjects.Methods: A total of 30 childhood-onset systemic lupus erythematosus and 39 healthy participants who were seronegative for hepatitis A received two doses of the hepatitis A vaccine in a 0- and 6-month schedule. Hepatitis A virus (HAV) IgG antibodies were measured before vaccination and 7 months after the vaccination.Results: Although anti-HAV IgG antibody titers after vaccination were found to be somewhat lower in children with systemic lupus erythematosus than that of the healthy subjects ( p < 0.05), the difference in seroconversion rate was insignificant between childhood-onset systemic lupus erythematosus patients ( n = 24/30, 80%) and healthy controls ( n = 33/39, 84.6%). There was no increase in median Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2K scores and anti-ds DNA levels after the vaccination procedure. Seroconversion rates in childhood-onset systemic lupus erythematosus patients were not affected by medication, high disease activity (SLEDAI-2K >6) and anti-ds DNA positivity. None of the patients experienced any flare or adverse reaction throughout the study.Conclusions: According to these results, we conclude that inactivated hepatitis A vaccine is safe and well tolerated in childhood-onset systemic lupus erythematosus patients, with no adverse events or increase in activity. Immunogenicity to the hepatitis A vaccine was adequate, with a seropositivity rate of 80%.