Design of specific inhibitors of quinolinate synthase based on [4Fe–4S] cluster coordination12. Issue 26 (11th March 2019)

• Record Type: Journal Article
• Authors: Saez Cabodevilla, Jaione; Volbeda, Anne; Hamelin, Olivier; Latour, Jean-Marc; Gigarel, Océane; Clémancey, Martin; Darnault, Claudine; Reichmann, Debora; Amara, Patricia; Fontecilla-Camps, Juan C.; Ollagnier de Choudens, Sandrine
• Is Part Of: Chemical communications. Volume 55:Issue 26(2019)
• Page Start: 3725
• Page End: 3728
• Publication Date: 2019-03-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09023h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A multidisciplinary approach allowed to identify specific inhibitors of quinolinate synthase, a [4Fe–4S]-containing enzyme involved in the formation of quinolinic acid and their action mode. Abstract : Quinolinate synthase (NadA) is a [4Fe–4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.