Biocompatible ruthenium polypyridyl complexes as efficient radiosensitizers. Issue 13 (6th March 2019)

• Record Type: Journal Article
• Authors: Xiong, Zushuang; Zhong, Jing-Xiang; Zhao, Zhennan; Chen, Tianfeng
• Is Part Of: Dalton transactions. Volume 48:Issue 13(2019)
• Page Start: 4114
• Page End: 4118
• Publication Date: 2019-03-06
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c9dt00333a
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A biocompatible ruthenium polypyridyl complex has been rationally designed, which could self-assemble into nanoparticles in aqueous solution to enhance the solubility and biocompatibility, and could synergistically realize simultaneous cancer chemo-radiotherapy. Abstract : A biocompatible ruthenium polypyridyl complex has been rationally designed and synthesized, which self-assembles into nanoparticles in aqueous solution to enhance the water solubility and biocompatibility. When activated by X-rays, the nanostructure synergistically triggers ROS overproduction in cancer cells to induce mitochondrial dysfunction and cell cycle arrest, thus realizing simultaneous chemo-radiotherapy.