Cobalt-catalyzed synthesis of N-containing heterocycles via cyclization of ortho-substituted anilines with CO2/H2. Issue 7 (8th March 2019)

• Record Type: Journal Article
• Authors: Ke, Zhengang; Yu, Bo; Wang, Huan; Xiang, Junfeng; Han, Juanjuan; Wu, Yunyan; Liu, Zhenghui; Yang, Peng; Liu, Zhimin
• Is Part Of: Green chemistry. Volume 21:Issue 7(2019)
• Page Start: 1695
• Page End: 1701
• Publication Date: 2019-03-08
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc00095j
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : The CO2 -involved synthesis of chemicals is of great significance from the green and sustainable chemistry viewpoint. Abstract : The CO2 -involved synthesis of chemicals is of great significance from the green and sustainable chemistry viewpoint. Herein, we report a non-noble metal catalytic system composed of CoF2, CsF and P(CH2 CH2 PPh2 )3 (denoted as P P 3 ) for the synthesis of N-containing heterocycles from ortho -substituted anilines and CO2 /H2 . Mechanism investigation indicates that [Co(P P 3 )H(CO2 )] + is a catalytically active intermediate under working conditions; and CsF plays important roles in activating ortho -substituted anilines via hydrogen bond interactions, thus promoting the formation of the final products. This catalytic system is highly efficient, and allows a wide scope of ortho -substituted anilines, together with excellent functional group tolerance, affording various N-containing heterocycles in good to excellent yields.