Filtration-histogram based magnetic resonance texture analysis (MRTA) for glioma IDH and 1p19q genotyping. Issue 113 (April 2019)

• Record Type: Journal Article
• Authors: Lewis, Martin A.; Ganeshan, Balaji; Barnes, Anna; Bisdas, Sotirios; Jaunmuktane, Zane; Brandner, Sebastian; Endozo, Raymond; Groves, Ashley; Thust, Stefanie C.
• Is Part Of: European journal of radiology. Issue 113(2019)
• Page Start: 116
• Page End: 123
• Publication Date: 2019-04
• Subjects: IDH Isocitrate Dehydrogenase -- IDHmut Isocitrate Dehydrogenase mutation -- IDHwt Isocitrate Dehydrogenase wild type -- IDHmut1p19qdel Isocitrate Dehydrogenase mutant gliomas with combined deletion of the short arm of chromosome 1 and the long arm of chromosome 19 -- IDHmut1p19qint Isocitrate Dehydrogenase mutant gliomas with intact short arm of chromosome 1 and long arm of chromosome 19 -- MRTA magnetic resonance imaging texture analysis -- SSF spatial scale filter -- WHO World Health Organization -- s.d. standard deviation -- m.p.p. mean of positive pixels; Glioma -- Brain tumour -- Texture analysis -- Isocitrate dehydrogenase -- 1p19q codeletion; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.02.014
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Preoperative glioma molecular subtyping impacts on the prognosis, surgical strategy and adjuvant therapy. Filtration-histogram texture analysis to identify glioma IDH and 1p19q status could be suitable for clinical application. T1+Gad, T2 and ADC texture parameters may support the distinction of glioma types. Abstract: Background: To determine if filtration-histogram based texture analysis (MRTA) of clinical MR imaging can non-invasively identify molecular subtypes of untreated gliomas. Methods: Post Gadolinium T1-weighted (T1+Gad) images, T2-weighted (T2) images and apparent diffusion coefficient (ADC) maps of 97 gliomas (54 = WHO II, 20 = WHO III, 23 = WHO IV) between 2010 and 2016 were studied. Whole-tumor segmentations were performed on a proprietary texture analysis research platform (TexRAD, Cambridge, UK) using the software's freehand drawing tool. MRTA commences with a filtration step, followed by quantification of texture using histogram texture parameters. Results were correlated using non-parametric statistics with a logistic regression model generated. Results: T1+Gad performed best for IDH typing of glioblastoma (sensitivity 91.9%, specificity 100%, AUC 0.945) and ADC for non-Gadolinium-enhancing gliomas (sensitivity 85.7%, specificity 78.4%, AUC 0.877). T2 was moderately precise (sensitivity 83.1%, specificity 78.9%, AUC 0.821). Excellent results for IDH typing were achieved from a combination of the three sequences (sensitivity 90.5%, specificity 94.5%, AUC = 0.98). For discriminating 1p19q genotypes, ADC produced the best results using unfiltered textures (sensitivity 80.6%, specificity 89.3%, AUC 0.811). Conclusion: Preoperative glioma genotyping with MRTA appears valuable with potential for clinical translation. The optimal choice of texture parameters is influenced by sequence choice, tumour morphology and segmentation method.