Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy. Issue 113 (April 2019)

• Record Type: Journal Article
• Authors: Martens, Roland M.; Noij, Daniel P.; Koopman, Thomas; Zwezerijnen, Ben; Heymans, Martijn; de Jong, Marcus C.; Hoekstra, Otto S.; Vergeer, Marije R.; de Bree, Remco; Leemans, C. René; de Graaf, Pim; Boellaard, Ronald; Castelijns, Jonas A.
• Is Part Of: European journal of radiology. Issue 113(2019)
• Page Start: 39
• Page End: 50
• Publication Date: 2019-04
• Subjects: 18F-FDG-PET 18FFluorodeoxyglucose positron-emission tomography -- ADC apparent diffusion coefficient -- CT computed tomography -- DWI diffusion-weighted Imaging -- GTV gross tumor volume -- MATV metabolic active tumor volume -- LR locoregional recurrence -- SUV standard uptake value -- TLG total lesion glycolysis -- TF treatment failure; Head and neck -- Squamous cell carcinoma -- DWI -- MRI -- PET -- Prognosis; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.01.031
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Background and purpose: In head and neck squamous cell carcinoma (HNSCC) (chemo)radiotherapy is increasingly used to preserve organ functionality. The purpose of this study was to identify predictive pretreatment DWI- and 18 F-FDG-PET/CT-parameters for treatment failure (TF), locoregional recurrence (LR) and death in HNSCC patients treated by (chemo)radiotherapy. Materials and methods: We retrospectively included 134 histologically proven HNSCC patients treated with (chemo)radiotherapy between 2012-2017. In 58 patients pre-treatment DWI and 18 F-FDG-PET/CT were performed, in 31 patients DWI only and in 45 patients 18 F-FDG-PET/CT only. Primary tumor (PT ) and largest lymph node (LN ) metastasis were quantitatively assessed for TF, LR and death. Multivariate analysis was performed for 18 F-FDG-PET/CT and DWI separately and thereafter combined. In patients with both imaging modalities, positive and negative predictive value in TF and differences in LR and death, were assessed. Results: Mean follow-up was 25.6 months (interquartile-range; 14.0–37.1 months). Predictors of treatment failure, corrected for TNM-stage and HPV-status, were SUVmax-PT, ADCmax-PT, total lesion glycolysis (TLG-LN ), ADCp20-LN (P = 0.049, P = 0.024, P = 0.031, P = 0.047, respectively). TLG-PT was predictive for LR (P = 0.003). Metabolic active tumor volume (MATV-PT ) (P = 0.003), ADCGTV-PT (P < 0.001), ADCSD (P = 0.048) were significant predictors for death. In patients with both imaging modalities SUVmax-PT remained predictive for treatment failure (P = 0.049), TLG-LN for LR (P = 0.003) and ADCGTV-PT for death (P < 0.001). Higher predictive value for treatment failure was found for the combination of SUVmax-PT and ADCmax-PT, compared to either one separately. Conclusion: Both DWI- and 18 F-FDG-PET/CT-parameters appear to have predictive value for treatment failure, locoregional recurrence and death. Combining SUVmax-PT and ADCmax-PT resulted in better prediction of treatment failure compared to single parameter assessment.