Teleost contributions to the understanding of mycobacterial diseases. (July 2019)

• Record Type: Journal Article
• Authors: Hodgkinson, Jordan W.; Belosevic, Miodrag; Elks, Philip M.; Barreda, Daniel R.
• Is Part Of: Developmental and comparative immunology. Volume 96(2019)
• Page Start: 111
• Page End: 125
• Publication Date: 2019-07
• Subjects: Mycobacterial diseases -- Host-microbe interactions -- Teleost models -- Zebrafish -- Comparative immunology; Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2019.02.011
• Languages: English
• ISSNs: 0145-305X

Abstract

Abstract: Few pathogens have shaped human medicine as the mycobacteria. From understanding biological phenomena driving disease spread, to mechanisms of host-pathogen interactions and antibiotic resistance, the Mycobacterium genus continues to challenge and offer insights into the basis of health and disease. Teleost fish models of mycobacterial infections have progressed significantly over the past three decades, now supplying a range of unique tools and new opportunities to define the strategies employed by these Gram-positive bacteria to overcome host defenses, as well as those host antimicrobial pathways that can be used to limit its growth and spread. Herein, we take a comparative perspective and provide an update on the contributions of teleost models to our understanding of mycobacterial diseases. Highlights: Update on the contributions of teleost models to our understanding of mycobacterial diseases. Build on previous findings from mammalian systems. Highlight strengths and limitations of teleost models. Focus on zebrafish and goldfish studies (molecular, in vitro, in vivo). Examine unique features of distinct mycobacterial infections.